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MAXAQUIN (LOMEFLOXACIN HYDROCHLORIDE) TABLETS: DOSAGE AND ADMINISTRATION

Maxaquin (Lomefloxacin HCl) may be taken without regard to meals. Sucralfate and antacids containing magnesium or aluminum, or Videx (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution should not be taken within 4 hours before or 2 hours after taking lomefloxacin. Risk of reaction to solar UVA light may be reduced by taking Maxaquin at least 12 hours before exposure to the sun (eg, in the evening).

Treatment

Patients with normal renal function

The recommended daily dose of Maxaquin is described in the following chart:

Infection Unit Dose Frequency Duration Daily Dose
Acute bacterial exacerbation of chronic bronchitis 400 mg qd 10 days 400 mg
Uncomplicated cystitis in females caused by E coli 400 mg qd 3 days 400 mg
Uncomplicated cystitis caused by K pneumoniae, P mirabilis, or S Saprophyticus 400 mg qd 10 days 400 mg
Complicated UTI 400 mg qd 14 days 400 mg


Elderly patients

No dosage adjustment is needed for elderly patients with normal renal function (ClCr >= 40 mL/min/ 1.73 m2).

Patients with impaired renal function

Lomefloxacin is primarily eliminated by renal excretion. Modification of dosage is recommended in patients with renal dysfunction. In patients with a creatinine clearance > 10 mL/min/1.73 m2 but < 40 mL/min/1.73 m2, the recommended dosage is an initial loading dose of 400 mg followed by daily maintenance doses of 200 mg (1/2 tablet) once daily for the duration of treatment. It is suggested that serial determinations of lomefloxacin levels be performed to determine any necessary alteration in the appropriate next dosing interval.

Dialysis patients

Hemodialysis removes only a negligible amount of lomefloxacin (3% in 4 hours). Hemodialysis patients should receive an initial loading dose of 400 mg followed by daily maintenance doses of 200 mg (1/2 tablet) once daily for the duration of treatment.

Patients with cirrhosis

Cirrhosis does not reduce the nonrenal clearance of lomefloxacin. The need for a dosage reduction in this population should be based on the degree of renal function of the patient and on the plasma concentrations.

Prevention / Prophylaxis

The recommended dose of Maxaquin (Lomefloxacin) is described in the following chart:

Procedure Dose Oral Administration
Transrectal prostate biopsy 400 mg single dose 1.6 hours prior to procedure
Transurethral surgical procedures 400 mg single dose 2.6 hours prior to procedure




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